ETHYL ESTERS OF ALPHA-LINOLENIC ACID
The world’s first preparation with ALA ethyl esters. Developed by Dr Andrzej Vogt through an anoxic esterification process. A pure, micellar form for people who want to consciously support the body where the modern diet most often loses balance: at the intersection of Omega‑6 : Omega‑3, oxidative stress and everyday regeneration.
Technology essence
- The ester form supports micelle formation and convenient absorption.
- Process carried out in an N₂ atmosphere – with emphasis on oxygen control during manufacturing.
- Transparency direction: batch COA (PV / AV / TOTOX + control of cyanogenic compounds).
Omega‑6 : Omega‑3
A high Omega‑6 : Omega‑3 ratio is a clear pro-inflammatory signal — the longer it persists, the harder it becomes to restore metabolic balance.
First get to know the product, then check buyer reviews and order
We are not asking for blind trust. You can go straight to the official store or first check current customer reviews on Allegro and come back to buy when you decide that ESTRALA is the right choice for you.
EXPERTS BEHIND ESTRALA TECHNOLOGY
A Polish innovation under the patronage of distinguished scientists with many years of experience in biotechnology and medicine.
DR ANDRZEJ VOGT
“52 developed technologies, 16 implemented industrially. There is no room for compromise in science.”
PROF. DR HAB. JERZY GUBERNATOR
“It’s not what you eat, but what you absorb. Ethyl esters form micelles of nanoparticle size.”
PROF. DR HAB. TADEUSZ TRZISZKA
“ESTRALA technology is an example of Polish biotechnological thought at world level.”
PROF. DR HAB. BARBARA BAŻANOW
“Cooperation on an antiviral medicine – 12 viruses destroyed, including coronavirus.”
DR ANDRZEJ VOGT
Creator of the anoxic esterification technology
“When we give fish oil, we give end metabolites – the body has no control. When we give ALA, we give clay from which the body itself makes as much EPA and DHA as it needs. I have used it for over 10 years and I do not admit my actual age to anyone. My friends call ALA the Elixir of Youth because that’s how it works for them.”
76 YEARS OF EXPERIENCE
Specialist in chemical technology, synthesis and esterification of fatty acids
16 TECHNOLOGIES IMPLEMENTED
Industrial production in Poland and worldwide
POLISH PATENT
Patented esterification method in a nitrogen atmosphere
SCIENTIFIC COOPERATION
University of Wrocław, University of Life Sciences
Team and laboratory
Formally: company registration in Warsaw. Operationally: R&D, quality control and batch preparation in Wrocław — in the place where the creators of the preparation work every day.
15 years of iteration
Company registered in Warsaw. Laboratory and production in Wrocław.
ESTRALA is a company registered in Warsaw. The heart of the project — the team and the laboratory — operates in Wrocław, where the creators of the preparation live and work every day.
Production — “less, but better”
For years the preparation was produced in short, controlled series and went mainly to the team’s close circle. This model imposed rigor: first repeatability and quality, only then broader availability.
What we document
The COA section on the site is prepared to publish batch results (as soon as they are made available).
A story that started “by accident” — and continues to this day
About 15 years ago, during chemical research on the stability of lipid fractions, a sample with an unusual profile and surprising purity was created in the laboratory. Instead of treating it as a curiosity, the team treated it as a starting point: over the following years the process conditions, oxygen control and purification method were refined — until the form we now call ESTRALA Pure ALA.
For most of that time, production took the form of short, controlled series — the preparation went mainly to a trusted circle of the doctor’s friends and to personal use. Only when the standards of stability and repeatability had been fully established did the project emerge from “laboratory silence” and become available more widely.
R&D‑driven, not marketing‑driven
Project decisions are made “from analysis to capsule”: parameters first, narrative second.
Iterations and improvements
The version available today is the result of many years of iteration: optimization of the process, stability and purity profile.
Warsaw ↔ Wrocław
Formally Warsaw, operationally Wrocław — where the creators of the preparation work in the laboratory.
Doctor Vogt — consistency and curiosity
Despite his advanced age, he remains professionally active and works on further concepts in the spirit of responsible science.
Anecdote from the laboratory
There is a joke within the team that asking the doctor’s age is “more difficult than a purity analysis”: the doctor smiles and avoids a clear answer, and most people still consistently underestimate his age. It is not a promise — rather an image of the energy he brings to the work. For us, only one thing matters: new projects are still being created in the laboratory, and standards never grow old.
This is part of the brand’s history and team culture. For customers, the most important thing is that the technology is still being developed with the same consistency with which it was created over the years.
CHRONIC INFLAMMATION AND THE NF-κB MECHANISM
Inflammation is the body’s natural defensive response. The problem begins when it becomes chronic — destroying the body from the inside for weeks, months and even years.
A SILENT PROCESS OF CELL DESTRUCTION
In every cell there is a protein NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells). At rest it is inactive. Under the influence of oxidative stress, environmental toxins or a diet rich in Omega‑6 fatty acids, it translocates to the cell nucleus and activates a cascade of inflammatory reactions.
The modern Western diet provides Omega‑6 and Omega‑3 fatty acids in a ratio of 40:1 (in the USA) or 16:1 (in Europe), while the optimal ratio is 4:1. This disproportion promotes chronic, diffuse inflammation.
LINK TO INFLAMMATORY STATES
Studies and literature reviews indicate that as many as 20–25% of cancers may be linked to chronic inflammation. That is why a long-term disturbed fat balance, oxidative stress and NF‑κB activation are not a minor detail — they create the biological background of diseases that develop over years.
Markers that show inflammatory background (to discuss with your doctor)
If you want to approach the topic methodically, start with simple laboratory parameters and interpret them in the context of lifestyle.
- hs‑CRP — a non-specific inflammatory marker
- Lipid profile — TG, HDL, LDL, non‑HDL
- Glukoza / HbA1c — metabolic background
- Complete blood count + ferritin — when your doctor recommends extending the panel
How we interpret evidence on the website
We separate biochemical mechanisms from batch quality data — therefore for every claim we look for indicators and sources that can be verified.
- Mechanism (in vitro) ≠ clinical setting (ludzie)
- Conclusions depend on dose, time i meal (lipidy)
- We describe fat stability through PV/AV/TOTOX (COA)
Where does the imbalance come from?
- High intake of refined vegetable oils (Omega‑6) in processed foods.
- Low intake of Omega‑3 sources in everyday meals.
- A change in the fatty acid profile of the food chain over the decades.
Target: 4:1
The higher the Omega‑6 : Omega‑3 ratio, the stronger the warning signal for the body’s inflammatory balance.
BLOCKING NF-κB TRANSLOCATION WITH ALA ESTERS
Alpha-linolenic acid in the form of ethyl esters acts as a biochemical blocker of the inflammatory process at the molecular level.
ALA ethyl esters physically prevent the translocation of NF‑κB protein from the cytoplasm to the cell nucleus. By incorporating into cell membranes, they displace pro-inflammatory arachidonic acid (Omega-6) and restore the natural balance of fatty acids. The effect: shutting down the inflammatory cascade before it can damage cellular DNA.
NF-κB BLOCKADE
ALA esters inhibit translocation of the NF‑κB transcription factor, silencing the inflammatory signal at the level of gene expression.
RESTORATION OF THE 4:1 RATIO
Displacing arachidonic acid from cell membranes restores the physiological Omega‑6 to Omega‑3 ratio.
REPAIR OF CELL MEMBRANES
Phospholipids and ALA esters rebuild the integrity of the lipid bilayer, restoring proper intercellular communication.
PROTECTION OF GENETIC MATERIAL
Antioxidant action protects DNA from mutations caused by reactive oxygen species (ROS) and oxidative stress.
WHY ALA ESTERS AND NOT EPA/DHA FISH OILS?
The fundamental difference between a precursor (ALA) and end metabolites (EPA/DHA) — and why it matters for your body.
Fish oils provide ready-made EPA and DHA — end metabolites. The body has no control over their amount. By providing ALA esters, you supply a precursor from which the body synthesizes exactly as much EPA and DHA as it currently needs. Excess ALA is safely excreted, whereas excess EPA/DHA may be directed onto hazardous metabolic pathways.
| Parameter | ESTRALA (ALA esters) | Fish oils (EPA/DHA) |
|---|---|---|
| Type of compound Biochemical classification | ✓ Precursor – the body controls synthesis | ✗ End metabolites – no control |
| Body control Homeostasis regulation | ✓ Full – EPA/DHA synthesis on demand | ✗ None – ready-made metabolites |
| Risk of overdosing Use safety | ✓ None – excess excreted | Possible at doses >1 g/day |
| Toxicological studies National Centre of Toxicology | ✓ 0 effects at >12,000 mg/kg | Requires dose limitation |
| Cancer risk Studies UK/USA/Canada | ✓ No data on increased risk | ✗ +40% prostate/ovarian cancer at 3–5 g/day |
| Cyanohydrins Toxic cyanogenic compounds | ✓ 100% removed (anoxic process) | Not applicable |
| Oxidative stability Resistance to oxidation | ✓ High (production in an N₂ atmosphere) | Variable – they go rancid quickly |
| Additional components Nutritional value | ✓ Phytosterols, lignans, vit. A/D/E/K2, lecithin | ✗ Only EPA/DHA |
| Hormonal support Phytosterols and lignans | ✓ Relief of menopausal symptoms | ✗ None |
| Source Origin of raw material | ✓ Plant-based (flax) – sustainable | Fish – heavy metals, overfishing |
“When we give fish oil, we give end metabolites – the body has no control. When we give ALA, we give clay from which the body itself makes as much EPA and DHA as it needs. That is the fundamental difference in the approach to supplementation.”
ESTRALA PURE ALA – ESTERIFICATION TECHNOLOGY
The world’s first preparation with ethyl esters of alpha-linolenic acid. Industrial production for over 24 years.
The process in 3 steps
“Hard” parameters
Instead of generalities — a prepared place for publishing batch data (COA). The most important indicators for lipids:
ANOXIC ESTERIFICATION PROCESS
Traditional flaxseed oil contains valuable fatty acids trapped in large triglyceride molecules, surrounded by toxic cyanogens (linamarin, lotaustralin). Dr Vogt’s team applied esterification in a nitrogen atmosphere — a process that:
1. Breaks glycerol bonds, releasing free fatty acids.
2. Combines them with ethanol, creating small, stable ethyl esters.
3. Eliminates 100% of cyanohydrins under controlled conditions.
Result: a molecule that is smaller, more stable and micellarly bioavailable — ready for immediate absorption in the small intestine.
0% toxins
Removed cyanohydrins
Fast absorption
Small ester molecules
Stability
Production in an N₂ atmosphere
60% ALA
Highest content
STORAGE
- Temperature 5°C (refrigerator)
- Protect from light
- Glass containers (not plastic)
- Avoid contact with oxygen
THE SCIENCE BEHIND ETHYL ESTERS
Learn about the biochemical processes that occur after taking ALA esters.
ANOXIC ESTERIFICATION
A process carried out in a nitrogen atmosphere (N₂) allows isolation of pure ALA while simultaneously removing 100% of cyanogenic compounds. Temperature and pressure are controlled with pharmaceutical precision.
MITOCHONDRIAL REGENERATION
ALA esters repair mitochondrial membranes, increasing the efficiency of ATP (adenosine triphosphate) production — the main energy carrier in cells.
MICELLAR BIOAVAILABILITY
Small ester molecules spontaneously form nanometric micelles. Absorption in the small intestine occurs without the involvement of pancreatic lipase.
NF-κB INHIBITION
ALA incorporated into cell membranes physically blocks translocation of the NF‑κB transcription factor, inhibiting expression of pro-inflammatory genes (IL-1β, IL-6, TNF-α).
RESULTS OF CLINICAL AND PRECLINICAL STUDIES
We bring together scientific literature, quality standards and the reporting plan (COA) to distinguish biochemical mechanisms from hard batch-control data.
LIPID SAFETY AND STABILITY
In lipids, oxidation is crucial. That is why anoxic technology (N₂) is combined with reporting of stability indicators (PV/AV/TOTOX) and control of raw-material purity.
ALA – MECHANISMS IN THE LITERATURE
Studies describe the influence of ALA and omega‑3 on inflammatory signalling (including NF‑κB pathways) and lipid metabolism. On the website we collect bibliography and clearly mark the level of evidence.
ETHYL ESTER FORM (EE)
The literature compares the bioavailability of different omega‑3 forms (EE, TAG, PL). Results depend on the protocol, dose and the presence of fat in the meal — which is why at ESTRALA we focus on transparent methods and batch documentation.
TOXICOLOGICAL STUDIES
The National Centre of Toxicology conducted comprehensive safety studies of ALA ethyl esters. Result: no acute or chronic toxicity even at extreme doses.
CARDIOVASCULAR REGENERATION
Studies in rats after experimental myocardial infarction showed full recovery of performance within 3–4 weeks with ALA ester supplementation.
TYPE 2 DIABETES
Clinical studies observed normalization of glucose levels in patients with type 2 diabetes. A drop in glycaemia from 300–320 mg/dl to 115–120 mg/dl.
DR VOGT’S PRECLINICAL STUDIES
Note: The information below concerns only preclinical studies (on animals) conducted by Dr Andrzej Vogt. The ESTRALA preparation has not been clinically studied in oncology and no human studies have been conducted in this area.
As part of preclinical research, Dr Vogt observed the effect of ALA esters on animal models. The results of these preliminary studies are promising from the point of view of further research directions, however they do not constitute a basis for formulating claims about the product’s medicinal effect.
ESTRALA Pure ALA is a food supplement that may support the body’s proper functioning. It is not a medicine and does not replace oncological treatment. People with cancer should always consult supplementation with their attending physician.
LEGAL INFORMATION
The presented preclinical study results are for informational purposes only and do not constitute a basis for using the preparation for medicinal purposes. ESTRALA Pure ALA is a food supplement. A food supplement should not be used as a substitute for a varied diet. Before starting supplementation, consult your doctor, especially in the case of chronic diseases, medication use or pregnancy.
Scientific basis and bibliography
We are expanding the website with increasingly precise sources. Below you will find selected publications and reference documents concerning ALA, the Omega‑6/Omega‑3 balance and inflammatory processes. This is general literature — it is not a study of a specific product.
ALA – authorised EU position (EFSA)
The European Food Safety Authority (EFSA) assessed the evidence for ALA, among others in the context of maintaining normal blood cholesterol levels (scientific opinion, Article 13).
Ethyl ester form – bioavailability reviews
The literature compares the bioavailability of omega‑3 in the form of ethyl esters (EE), triglycerides (TAG) and other forms. Conclusions depend on the protocol and concurrent fat intake.
- Schuchardt J.P., Hahn A. Omega‑3 long chain fatty acid “bioavailability”: A review of evidence and methodological considerations. Prostaglandins Leukot Essent Fatty Acids (2013/2014). (Review)
- Comparative membrane incorporation of omega‑3 fish oil triglyceride vs ethyl ester… PLOS ONE (2022). doi:10.1371/journal.pone.0265462
Omega‑6 / Omega‑3 balance
The relationship between fatty acids in the diet is widely discussed in the context of lipid metabolism and inflammatory processes.
ALA metabolism and conversion to EPA/DHA
ALA is a precursor of long-chain omega‑3, but the degree of conversion in humans depends on many factors (including sex, diet and fatty-acid status).
- Burdge G.C., Calder P.C. Conversion of α‑linolenic acid to longer‑chain polyunsaturated fatty acids in human adults. Reproduction Nutrition Development (2005). doi:10.1051/rnd:2005047
- Baker E.J. i wsp. Metabolism and functional effects of plant‑derived omega‑3 fatty acids in humans. Progress in Lipid Research (2016). doi:10.1016/j.plipres.2016.07.002
Omega‑3, inflammation and NF‑κB pathways
The literature describes the effect of omega‑3 fatty acids on inflammatory mediators and the expression of genes related to the immune response.
How should evidence be read? Precision means distinction: mechanism (in vitro) ≠ preclinical study ≠ observation ≠ clinical study. The publications above provide scientific context for discussion of ALA and omega‑3 — they are not direct confirmation of the effect of a specific product.
BATCH CONTROL, STABILITY AND DATA TRANSPARENCY
We are expanding the service with increasingly precise quality data. Below we show the reporting standard (COA / protocols) — so that each batch is described by parameters, not slogans.
What we measure (COA framework)
Parameters and methods vary depending on the raw material and the process. Below is an example set of fields that we ultimately publish for a batch (in the form of a COA document):
- ALA ethyl ester profile — chromatography (e.g. GC‑FID/GC‑MS) + peak identification
- Lipid oxidation — PV / AV / TOTOX (freshness and stability indicators)
- Solvents and process residues — limits and compliance with standards
- Heavy metals — Pb, Cd, Hg, As (ICP methods)
- Microbiology — microbiological safety (depending on form and packaging)
- Water / water activity — parameters affecting stability
Why is this important? For fats, oxidation control is crucial. That is why at ESTRALA we place emphasis on oxygen control in the process and on reporting stability indicators.
Diagram: oxygen vs stability (illustrative)
The chart below is an illustrative diagram, showing the relationship: less oxygen in the process and storage → greater lipid stability. It is not the result of a specific batch study.
Ultimately: COA for each batch
This place is prepared for publication of a PDF “Certificate of Analysis” for each series (after the publication process is implemented).
MULTIDIRECTIONAL ACTION OF ALA ESTERS
Ethyl esters of alpha-linolenic acid support the proper functioning of many body systems.
COGNITIVE FUNCTIONS
Supports proper brain function and cognitive processes
CARDIOVASCULAR SYSTEM
Supports vessel elasticity and a proper lipid profile
MUSCLE REGENERATION
Accelerates rebuilding of muscle fibres after effort
IMMUNITY
Supports proper functioning of the immune system
HORMONAL SUPPORT
Phytosterols and lignans relieve menopausal symptoms
METABOLISM
Supports proper metabolism and weight control
SKIN AND HAIR
Repair of cell membranes improves skin condition
CELLULAR REGENERATION
Rebuilding membranes and protecting genetic material
PROTECTION AT EVERY STAGE OF LIFE
ESTRALA supports children’s development, the vitality of young adults and the health of seniors
SUPPORT FOR YOUR CHILD’S DEVELOPMENT
A child’s brain develops intensively and needs the right ingredients. ESTRALA provides the precursor of DHA — a key building fat for the brain and eyes. Omega‑3 fatty acids support proper cognitive development and help with concentration and learning.
Priorities
- Development of the nervous system and cognitive functions.
- Support for lipid balance in the diet.
- Simple, repeatable habits (regularity).
How to read the site
In the sections “Studies”, “Sources” and “Quality control (COA)” we separate biochemical mechanisms from batch quality data — so that communication is as transparent as possible.
HOW TO USE ESTRALA?
Simple dosing for maximum health benefits
RECOMMENDED DAILY DOSE
WHEN TO TAKE
BOTTLE EFFICIENCY
ESTRALA works reparatively — it rebuilds damaged cell membranes. You will notice the first effects after a few weeks of regular use. For full health benefits we recommend a minimum of 3 months of regular use.
TRAINING VIDEOS
Get to know ESTRALA through our educational and scientific videos
INTRODUCTION + EXPERTS
A comprehensive introduction to ALA ethyl esters with a presentation of the Scientific Council
SCIENCE AND RESEARCH
Deeper knowledge about mechanisms of action and scientific publications
FOR ATHLETES
Train hard, recover faster with ESTRALA
GMO – WHAT IS WORTH KNOWING
Important information about GMO and healthy food
WHY ALA ON THE MARKET
Reasons for introducing ALA esters to the market
OMEGA-3 FROM ALA ESTERS
How important Omega‑3 fatty acids delivered by ALA esters are for the body
FREQUENTLY ASKED QUESTIONS
Answers to the questions that may be on your mind
DO YOU HAVE QUESTIONS? CONTACT US
We will be happy to answer questions about the product, technology and cooperation opportunities.
CONTACT DETAILS
We are available Monday to Friday from 9:00 am to 5:00 pm. We respond to messages within 24 hours.
IMPORTANT LEGAL INFORMATION
In accordance with the Regulation of the Minister of Health of 9 October 2007 and EU regulations
DO NOT EXCEED THE RECOMMENDED PORTION
Do not exceed the recommended daily portion for consumption. The recommended daily dose is 10 ml.
DOES NOT REPLACE A DIET
A food supplement must not be used as a substitute (replacement) for a varied diet.
STORAGE
The food supplement should be stored out of the reach of small children.
THIS IS NOT A MEDICINE
ESTRALA Pure ALA is a food supplement, not a medicinal product. It does not have medicinal properties.
PRECLINICAL STUDIES
Information about Dr Vogt’s studies concerns preclinical studies (on animals). The preparation has not been clinically tested for the treatment of diseases.
MEDICAL CONSULTATION
In the case of chronic diseases, pregnancy or medication use, consult a doctor before starting supplementation.
PRODUCT INFORMATION
ESTRALA Pure ALA jest food supplement, intended to supplement the normal diet. The product is not a medicinal product and does not have properties for preventing or treating disease. A balanced and varied diet and a healthy lifestyle are the basis of good health. If you have doubts about your health status or the use of the product, we recommend consultation with a doctor or pharmacist.